| 2026-05-24 | Antofagasta v Deportes Santa Cruz | 1–1 | Regular Season - 13 |
| 2026-06-01 | Deportes Santa Cruz v Deportes Copiapo | 1–1 | Regular Season - 14 |
| 2026-06-07 | Rangers de Talca v Deportes Santa Cruz | 0–1 | Regular Season - 15 |
| 2026-06-19 | A. Italiano v Deportes Santa Cruz | 0–1 | Group Stage - 3 |
| 2026-06-27 | Deportes Santa Cruz v Palestino | 0–0 | Group Stage - 4 |
| 2026-07-05 | Deportes Santa Cruz v A. Italiano | 2–1 | Group Stage - 5 |
| 2026-07-11 | Palestino v Deportes Santa Cruz | 3–2 | Group Stage - 6 |
| 2026-07-25 | Cobreloa v Deportes Santa Cruz | 4–2 | Regular Season - 17 |
| 2026-08-02 | Deportes Santa Cruz v Santiago Wanderers | 1–3 | Regular Season - 18 |
| 2026-08-08 | Deportes Santa Cruz v D. Puerto Montt | 0–0 | Regular Season - 19 |
| 2026-08-14 | Curico Unido v Deportes Santa Cruz | 1–2 | Regular Season - 20 |
| 2026-08-17 | Deportes Santa Cruz v San Luis | 0–2 | Regular Season - 21 |
| 2026-08-22 | Magallanes v Deportes Santa Cruz | 1–0 | Regular Season - 22 |
| 2026-08-29 | Union San Felipe v Deportes Santa Cruz | 0–0 | Regular Season - 23 |
| 2026-09-05 | Deportes Santa Cruz v Union Espanola | 1–1 | Regular Season - 24 |
| 2026-09-09 | Deportes Iquique v Deportes Santa Cruz | 0–1 | Regular Season - 25 |
| 2026-09-14 | Deportes Santa Cruz v Recoleta | 0–0 | Regular Season - 26 |
| 2026-09-24 | O'Higgins v Deportes Santa Cruz | 2–1 | Round of 16 |
| 2026-09-27 | Deportes Santa Cruz v O'Higgins | 1–3 | Round of 16 |
| 2026-10-03 | Deportes Santa Cruz v San Marcos de Arica | 1–2 | Regular Season - 16 |
| 2026-10-10 | Deportes Temuco v Deportes Santa Cruz | 2–1 | Regular Season - 27 |
| 2026-10-18 | Deportes Santa Cruz v Antofagasta | — | Regular Season - 28 |
