| 1 | Kevin De Bruyne | VfL Wolfsburg | Manchester City Football Club | €76M | 30 August 2015 |
| 2 | Raheem Sterling | Liverpool Football Club | Manchester City Football Club | €63.7M | 14 July 2015 |
| 3 | Ángel Di María | Manchester United Football Club | Paris Saint-Germain Football Club | €63M | 6 August 2015 |
| 4 | Anthony Martial | Association sportive de Monaco Football Club | Manchester United Football Club | €60M | 1 September 2015 |
| 5 | Nicolás Otamendi | Valencia Club de Fútbol S. A. D. | Manchester City Football Club | €44.5M | 20 August 2015 |
| 6 | Paulo Dybala | Palermo FC | Juventus Football Club | €41M | 1 July 2015 |
| 7 | Arturo Vidal | Juventus Football Club | FC Bayern München | €39.3M | 28 July 2015 |
| 8 | Mateo Kovacic | Inter | Real Madrid Club de Fútbol | €38M | 18 August 2015 |
| 9 | Geoffrey Kondogbia | Association sportive de Monaco Football Club | Inter | €36M | 1 July 2015 |
| 10 | Morgan Schneiderlin | Southampton FC | Manchester United Football Club | €35M | 13 July 2015 |
| 11 | Memphis Depay | Eindhovense Voetbalvereniging Philips Sport Vereniging | Manchester United Football Club | €34M | 1 July 2015 |
| 12 | Carlos Bacca | Sevilla Fútbol Club S.A.D. | Associazione Calcio Milan | €33.3M | 3 July 2015 |
| 13 | Heung-min Son | Bayer Leverkusen | Tottenham Hotspur Football Club | €30M | 28 August 2015 |
| 14 | Alex Sandro | Futebol Clube do Porto | Juventus Football Club | €28M | 20 August 2015 |
| 15 | Álvaro Negredo | Manchester City Football Club | Valencia Club de Fútbol S. A. D. | €28M | 1 July 2015 |
| 16 | Abdul Rahman Baba | FC Augsburg | Chelsea Football Club | €26M | 16 August 2015 |
| 17 | Layvin Kurzawa | Association sportive de Monaco Football Club | Paris Saint-Germain Football Club | €25M | 27 August 2015 |
| 18 | Alessio Romagnoli | Associazione Sportiva Roma | Associazione Calcio Milan | €25M | 11 August 2015 |
| 19 | Giannelli Imbula | Futebol Clube do Porto | Stoke City | €24.3M | 1 February 2016 |
| 20 | Andrea Bertolacci | Associazione Sportiva Roma | Associazione Calcio Milan | €21M | 2 July 2015 |
| 21 | Georginio Wijnaldum | Eindhovense Voetbalvereniging Philips Sport Vereniging | Newcastle United Football Club | €20M | 11 July 2015 |
| 22 | Luciano Vietto | Villarreal Club de Fútbol S.A.D. | Club Atlético de Madrid S.A.D. | €20M | 7 July 2015 |
| 23 | Giannelli Imbula | Olympique de Marseille | Futebol Clube do Porto | €20M | 1 July 2015 |
| 24 | Ivan Perišić | VfL Wolfsburg | Inter | €19M | 30 August 2015 |
| 25 | Aleksandar Mitrović | Anderlecht | Newcastle United Football Club | €18.5M | 21 July 2015 |
| 26 | Florian Thauvin | Olympique de Marseille | Newcastle United Football Club | €18.4M | 19 August 2015 |
| 27 | Matteo Darmian | Torino Calcio | Manchester United Football Club | €18M | 11 July 2015 |
| 28 | Nathaniel Clyne | Southampton FC | Liverpool Football Club | €17.7M | 1 July 2015 |
| 29 | Xherdan Shaqiri | Inter | Stoke City | €17M | 11 August 2015 |
| 30 | Salomón Rondón | Zenit | West Brom | €17M | 10 August 2015 |
| 31 | Jonjo Shelvey | Swansea City | Newcastle United Football Club | €16M | 12 January 2016 |
| 32 | Toby Alderweireld | Club Atlético de Madrid S.A.D. | Tottenham Hotspur Football Club | €16M | 8 July 2015 |
| 33 | Andros Townsend | Tottenham Hotspur Football Club | Newcastle United Football Club | €15.7M | 27 January 2016 |
| 34 | Virgil van Dijk | The Celtic Football Club | Southampton FC | €15.7M | 1 September 2015 |
| 35 | Jordy Clasie | Feyenoord Rotterdam | Southampton FC | €15M | 15 July 2015 |
| 36 | Yannick Carrasco | Association sportive de Monaco Football Club | Club Atlético de Madrid S.A.D. | €15M | 10 July 2015 |
| 37 | Ivan Cavaleiro | Benfica | Association sportive de Monaco Football Club | €15M | 10 July 2015 |
| 38 | Casemiro | Futebol Clube do Porto | Real Madrid Club de Fútbol | €15M | 2 July 2015 |
| 39 | João Cancelo | Benfica | Valencia Club de Fútbol S. A. D. | €15M | 1 July 2015 |
| 40 | Roberto Pereyra | Udinese Calcio | Juventus Football Club | €15M | 1 July 2015 |
| 41 | Xherdan Shaqiri | FC Bayern München | Inter | €15M | 1 July 2015 |
| 42 | Clinton N'Jie | Olympique Lyonnais | Tottenham Hotspur Football Club | €14.1M | 15 August 2015 |
| 43 | Sergi Darder | Malaga | Olympique Lyonnais | €13.1M | 29 August 2015 |
| 44 | Charles Aránguiz | Internacional | Bayer Leverkusen | €13M | 13 August 2015 |
| 45 | Mohamed Elneny | FC Basel 1893 AG | Arsenal Football Club | €12.5M | 14 January 2016 |
| 46 | Andre Gray | Brentford Football Club | Burnley Football Club | €12.4M | 21 August 2015 |
| 47 | Ramiro Funes Mori | Club Atlético River Plate | Everton Football Club | €12.2M | 1 September 2015 |
| 48 | Rony Lopes | Manchester City Football Club | Association sportive de Monaco Football Club | €12M | 28 August 2015 |
| 49 | Sergej Milinković-Savić | Koninklijke Racing Club Genk | Società Sportiva Lazio S.p.A. | €12M | 6 August 2015 |
| 50 | Chancel Mbemba | Anderlecht | Newcastle United Football Club | €12M | 30 July 2015 |