| 1 | Jack Grealish | Aston Villa Football Club | Manchester City Football Club | €117.5M | 5 August 2021 |
| 2 | Romelu Lukaku | Inter | Chelsea Football Club | €113M | 12 August 2021 |
| 3 | Dušan Vlahović | Associazione Calcio Fiorentina | Juventus Football Club | €85.4M | 28 January 2022 |
| 4 | Jadon Sancho | Borussia Dortmund | Manchester United Football Club | €85M | 23 July 2021 |
| 5 | Achraf Hakimi | Inter | Paris Saint-Germain Football Club | €68M | 6 July 2021 |
| 6 | Ben White | Brighton and Hove Albion Football Club | Arsenal Football Club | €58.5M | 30 July 2021 |
| 7 | Ferran Torres | Manchester City Football Club | Futbol Club Barcelona | €55M | 1 January 2022 |
| 8 | Dayot Upamecano | RB Leipzig | FC Bayern München | €42.5M | 5 July 2021 |
| 9 | Bruno Guimarães | Olympique Lyonnais | Newcastle United Football Club | €42.1M | 30 January 2022 |
| 10 | Tammy Abraham | Chelsea Football Club | Associazione Sportiva Roma | €41M | 17 August 2021 |
| 11 | Raphaël Varane | Real Madrid Club de Fútbol | Manchester United Football Club | €40M | 14 August 2021 |
| 12 | Ibrahima Konaté | RB Leipzig | Liverpool Football Club | €40M | 1 July 2021 |
| 13 | Emiliano Buendía | Norwich | Aston Villa Football Club | €38.4M | 1 July 2021 |
| 14 | Josko Gvardiol | Dinamo Zagreb | RB Leipzig | €36.8M | 1 July 2021 |
| 15 | Fikayo Tomori | Chelsea Football Club | Associazione Calcio Milan | €35.3M | 1 July 2021 |
| 16 | Kurt Zouma | Chelsea Football Club | West Ham United Football Club | €35M | 28 August 2021 |
| 17 | Martin Ødegaard | Real Madrid Club de Fútbol | Arsenal Football Club | €35M | 20 August 2021 |
| 18 | Rodrigo De Paul | Udinese Calcio | Club Atlético de Madrid S.A.D. | €35M | 12 July 2021 |
| 19 | Leon Bailey | Bayer Leverkusen | Aston Villa Football Club | €32M | 4 August 2021 |
| 20 | Eduardo Camavinga | Stade Rennais Football Club | Real Madrid Club de Fútbol | €31M | 31 August 2021 |
| 21 | Chris Wood | Burnley Football Club | Newcastle United Football Club | €30M | 13 January 2022 |
| 22 | Lucas Digne | Everton Football Club | Aston Villa Football Club | €30M | 13 January 2022 |
| 23 | Nikola Vlašić | CSKA Moscow | West Ham United Football Club | €30M | 31 August 2021 |
| 24 | Donyell Malen | Eindhovense Voetbalvereniging Philips Sport Vereniging | Borussia Dortmund | €30M | 27 July 2021 |
| 25 | Joe Willock | Arsenal Football Club | Newcastle United Football Club | €29.4M | 13 August 2021 |
| 26 | Danny Ings | Southampton FC | Aston Villa Football Club | €29.4M | 4 August 2021 |
| 27 | Daniel James | Manchester United Football Club | Leeds United Association Football Club | €29.1M | 31 August 2021 |
| 28 | Aaron Ramsdale | Sheffield Utd | Arsenal Football Club | €28M | 20 August 2021 |
| 29 | Nico González | VfB Stuttgart | Associazione Calcio Fiorentina | €27.4M | 1 July 2021 |
| 30 | Marash Kumbulla | Verona Hellas Football Club | Associazione Sportiva Roma | €26.5M | 1 July 2021 |
| 31 | Tino Livramento | — | Southampton FC | €26.2M | 2 August 2021 |
| 32 | Yuri Alberto | Internacional | Zenit | €25M | 31 January 2022 |
| 33 | Emerson Royal | Futbol Club Barcelona | Tottenham Hotspur Football Club | €25M | 31 August 2021 |
| 34 | Bryan Gil | Sevilla Fútbol Club S.A.D. | Tottenham Hotspur Football Club | €25M | 26 July 2021 |
| 35 | Manuel Ugarte | Famalicao | Sporting CP | €24.5M | 9 August 2021 |
| 36 | Vitaliy Mykolenko | Dynamo Kyiv | Everton Football Club | €23.5M | 1 January 2022 |
| 37 | Arnaut Danjuma | Association Football Club Bournemouth | Villarreal Club de Fútbol S.A.D. | €23.5M | 19 August 2021 |
| 38 | Marc Guéhi | Chelsea Football Club | Crystal Palace Football Club | €23.3M | 18 July 2021 |
| 39 | Odilon Kossounou | Club Brugge Koninklijke Voetbalvereniging | Bayer Leverkusen | €23M | 22 July 2021 |
| 40 | Matteo Politano | Inter | Società Sportiva Calcio Napoli | €22.1M | 1 July 2021 |
| 41 | Weston McKennie | FC Schalke 04 | Juventus Football Club | €21.9M | 1 July 2021 |
| 42 | Julián Alvarez | Club Atlético River Plate | Manchester City Football Club | €21.4M | 31 January 2022 |
| 43 | Juan Musso | Udinese Calcio | Atalanta Bergamasca Calcio S.p.a. | €20.5M | 2 July 2021 |
| 44 | Gerson | Flamengo | Olympique de Marseille | €20.5M | 1 July 2021 |
| 45 | Boubakary Soumaré | Lille Olympique Sporting Club | LEI | €20M | 2 July 2021 |
| 46 | Eldor Shomurodov | Genoa Cricket and Football Club | Associazione Sportiva Roma | €19.8M | 2 August 2021 |
| 47 | Rodrigo Bentancur | Juventus Football Club | Tottenham Hotspur Football Club | €19M | 31 January 2022 |
| 48 | Takehiro Tomiyasu | Bologna Football Club 1909 | Arsenal Football Club | €18.6M | 31 August 2021 |
| 49 | Marc Cucurella | Getafe Club de Fútbol S. A. D. Team Dubai | Brighton and Hove Albion Football Club | €18M | 31 August 2021 |
| 50 | Angeliño | Manchester City Football Club | RB Leipzig | €18M | 1 July 2021 |