| 1 | Edin Dzeko | VfL Wolfsburg | Manchester City Football Club | €37M | 7 January 2011 |
| 2 | Ángel Di María | Benfica | Real Madrid Club de Fútbol | €33M | 1 July 2010 |
| 3 | Mario Balotelli | Inter | Manchester City Football Club | €29.5M | 12 August 2010 |
| 4 | James Milner | Aston Villa Football Club | Manchester City Football Club | €22M | 17 August 2010 |
| 5 | André-Pierre Gignac | Toulouse Football Club | Olympique de Marseille | €16M | 20 August 2010 |
| 6 | Leonardo Bonucci | — | Juventus Football Club | €15.5M | 1 July 2010 |
| 7 | Dmytro Chygrynskyi | Futbol Club Barcelona | FC Shakhtar Donetsk | €15M | 6 July 2010 |
| 8 | Simon Kjær | Palermo FC | VfL Wolfsburg | €12.5M | 8 July 2010 |
| 9 | Jérôme Boateng | Hamburger Sport Verein | Manchester City Football Club | €12.5M | 1 July 2010 |
| 10 | Zoran Tosic | Manchester United Football Club | CSKA Moscow | €9.5M | 1 July 2010 |
| 11 | Bebé | Guimaraes | Manchester United Football Club | €8.8M | 1 August 2010 |
| 12 | Chris Smalling | Fulham Football Club | Manchester United Football Club | €8M | 1 July 2010 |
| 13 | James Rodríguez | Club Atlético Banfield | Futebol Clube do Porto | €7.4M | 6 July 2010 |
| 14 | Mattia Destro | Inter | Genoa Cricket and Football Club | €6.5M | 1 January 2011 |
| 15 | Taison | Internacional | Metalist Kharkiv (- 2016) | €6.3M | 26 August 2010 |
| 16 | Marko Arnautovic | Football Club Twente | Werder Bremen | €6.2M | 1 July 2010 |
| 17 | Sergio Canales | — | Real Madrid Club de Fútbol | €6M | 1 July 2010 |
| 18 | César Azpilicueta | Club Atlético Osasuna | Olympique de Marseille | €6M | 1 July 2010 |
| 19 | Henrikh Mkhitaryan | Metalurg Donetsk (- 2015) | FC Shakhtar Donetsk | €5.9M | 30 August 2010 |
| 20 | Franco Jara | — | Benfica | €5.5M | 1 July 2010 |
| 21 | Gylfi Sigurdsson | Reading FC | 1899 Hoffenheim | €5.2M | 31 August 2010 |
| 22 | Ezequiel Muñoz | Club Atlético Boca Juniors | Palermo FC | €5M | 5 August 2010 |
| 23 | Robert Lewandowski | Lech Poznan | Borussia Dortmund | €4.8M | 1 July 2010 |
| 24 | Sokratis Papastathopoulos | Genoa Cricket and Football Club | Associazione Calcio Milan | €4.5M | 20 July 2010 |
| 25 | Nicolás Otamendi | Club Atlético Vélez Sársfield | Futebol Clube do Porto | €4M | 31 August 2010 |
| 26 | Facundo Bertoglio | — | Dynamo Kyiv | €3.6M | 1 July 2010 |
| 27 | Salomón Rondón | Las Palmas | Malaga | €3.5M | 19 July 2010 |
| 28 | José Sosa | FC Bayern München | Società Sportiva Calcio Napoli | €3M | 30 August 2010 |
| 29 | Ciprian Deac | CFR 1907 Cluj | FC Schalke 04 | €3M | 1 August 2010 |
| 30 | Matej Vydra | Baník Ostrava | Udinese Calcio | €3M | 1 July 2010 |
| 31 | Damien Marcq | — | Caen | €3M | 1 July 2010 |
| 32 | Bas Dost | Heracles Almelo | Sportclub Heerenveen | €2.8M | 1 July 2010 |
| 33 | Danny Wilson | Rangers Football Club | Liverpool Football Club | €2.8M | 1 July 2010 |
| 34 | Ivan Rakitic | FC Schalke 04 | Sevilla Fútbol Club S.A.D. | €2.5M | 28 January 2011 |
| 35 | Papu Gómez | Club Atlético San Lorenzo de Almagro | Catania FC | €2.5M | 21 July 2010 |
| 36 | Simon Mignolet | St. Truiden | Sunderland Association Football Club | €2.5M | 1 July 2010 |
| 37 | Domagoj Vida | NK Osijek | Bayer Leverkusen | €2.4M | 1 July 2010 |
| 38 | Marcos Alonso | — | — | €2.4M | 1 July 2010 |
| 39 | Marcos Rojo | Club Estudiantes de La Plata | Spartak Moscow | €2M | 1 January 2011 |
| 40 | Caner Erkin | CSKA Moscow | Fenerbahçe Spor Kulübü | €2M | 5 July 2010 |
| 41 | Olivier Giroud | — | Montpellier HSC | €2M | 1 July 2010 |
| 42 | Kyriakos Papadopoulos | Olympiakos Piraeus | FC Schalke 04 | €2M | 1 July 2010 |
| 43 | Jonjo Shelvey | — | Liverpool Football Club | €2M | 1 July 2010 |
| 44 | Roberto Rosales | Gent | Football Club Twente | €2M | 1 July 2010 |
| 45 | Diego Chará | Deportes Tolima | Portland Timbers | €1.8M | 14 April 2011 |
| 46 | Yuto Nagatomo | FC Tokyo | Cesena FC | €1.6M | 28 January 2011 |
| 47 | Nassim Ben Khalifa | Grasshoppers | VfL Wolfsburg | €1.6M | 1 July 2010 |
| 48 | Juan Manuel Insaurralde | Club Atlético Newell’s Old Boys | Club Atlético Boca Juniors | €1.5M | 1 July 2010 |
| 49 | Luis Muriel | Deportivo Cali | Udinese Calcio | €1.5M | 1 July 2010 |
| 50 | Chris Basham | — | — | €1.4M | 1 July 2010 |