| 1 | Kai Havertz | Bayer Leverkusen | Chelsea Football Club | €100M | 4 September 2020 |
| 2 | Arthur Melo | Futbol Club Barcelona | Juventus Football Club | €80.6M | 1 September 2020 |
| 3 | Victor Osimhen | Lille Olympique Sporting Club | Società Sportiva Calcio Napoli | €78.9M | 1 September 2020 |
| 4 | Rúben Dias | Benfica | Manchester City Football Club | €71.6M | 29 September 2020 |
| 5 | Miralem Pjanić | Juventus Football Club | Futbol Club Barcelona | €60M | 1 September 2020 |
| 6 | Timo Werner | RB Leipzig | Chelsea Football Club | €53M | 1 July 2020 |
| 7 | Ben Chilwell | LEI | Chelsea Football Club | €50.2M | 26 August 2020 |
| 8 | Thomas Partey | Club Atlético de Madrid S.A.D. | Arsenal Football Club | €50M | 5 October 2020 |
| 9 | Mauro Icardi | Inter | Paris Saint-Germain Football Club | €50M | 1 July 2020 |
| 10 | Leroy Sané | Manchester City Football Club | FC Bayern München | €49M | 15 July 2020 |
| 11 | Nathan Aké | Association Football Club Bournemouth | Manchester City Football Club | €45.3M | 5 August 2020 |
| 12 | Diogo Jota | Wolverhampton Wanderers Football Club | Liverpool Football Club | €44.7M | 19 September 2020 |
| 13 | Achraf Hakimi | Real Madrid Club de Fútbol | Inter | €43M | 1 September 2020 |
| 14 | Fábio Silva | Futebol Clube do Porto | Wolverhampton Wanderers Football Club | €40M | 5 September 2020 |
| 15 | Hakim Ziyech | Ajax | Chelsea Football Club | €40M | 1 July 2020 |
| 16 | Donny van de Beek | Ajax | Manchester United Football Club | €39M | 2 September 2020 |
| 17 | Nicolò Barella | Cagliari Calcio | Inter | €38.5M | 1 September 2020 |
| 18 | Dominik Szoboszlai | Red Bull Salzburg | RB Leipzig | €36M | 1 January 2021 |
| 19 | Wesley Fofana | AS Saint-Étienne | LEI | €35M | 2 October 2020 |
| 20 | Álvaro Morata | Chelsea Football Club | Club Atlético de Madrid S.A.D. | €35M | 1 July 2020 |
| 21 | Ollie Watkins | Brentford Football Club | Aston Villa Football Club | €34M | 9 September 2020 |
| 22 | Darwin Núñez | Almeria | Benfica | €34M | 4 September 2020 |
| 23 | Ferran Torres | Valencia Club de Fútbol S. A. D. | Manchester City Football Club | €33.5M | 4 August 2020 |
| 24 | Nélson Semedo | Futbol Club Barcelona | Wolverhampton Wanderers Football Club | €32M | 23 September 2020 |
| 25 | Giovani Lo Celso | Real Betis Balompié S.A.D. | Tottenham Hotspur Football Club | €32M | 1 July 2020 |
| 26 | Francisco Trincão | SC Braga | Futbol Club Barcelona | €30.9M | 3 August 2020 |
| 27 | Jude Bellingham | — | Borussia Dortmund | €30.2M | 23 July 2020 |
| 28 | Sergio Reguilón | Real Madrid Club de Fútbol | Tottenham Hotspur Football Club | €30M | 19 September 2020 |
| 29 | Moisés Caicedo | — | Brighton and Hove Albion Football Club | €28.2M | 1 February 2021 |
| 30 | Ben Godfrey | Norwich | Everton Football Club | €27.5M | 5 October 2020 |
| 31 | Amad Diallo | Atalanta Bergamasca Calcio S.p.a. | Manchester United Football Club | €27.3M | 2 January 2021 |
| 32 | Yannick Carrasco | — | Club Atlético de Madrid S.A.D. | €27M | 8 September 2020 |
| 33 | Jonathan David | Gent | Lille Olympique Sporting Club | €27M | 11 August 2020 |
| 34 | Patrik Schick | Associazione Sportiva Roma | Bayer Leverkusen | €26.5M | 8 September 2020 |
| 35 | Nicolò Rovella | Genoa Cricket and Football Club | Juventus Football Club | €26M | 28 January 2021 |
| 36 | Jérémy Doku | Anderlecht | Stade Rennais Football Club | €26M | 5 October 2020 |
| 37 | Rhian Brewster | — | Sheffield Utd | €26M | 2 October 2020 |
| 38 | Stefano Sensi | Unione Sportiva Sassuolo Calcio | Inter | €25M | 1 September 2020 |
| 39 | Emre Can | Juventus Football Club | Borussia Dortmund | €25M | 1 July 2020 |
| 40 | Edouard Mendy | Stade Rennais Football Club | Chelsea Football Club | €24M | 24 September 2020 |
| 41 | Gianluca Mancini | Atalanta Bergamasca Calcio S.p.a. | Associazione Sportiva Roma | €24M | 1 September 2020 |
| 42 | Saïd Benrahma | Brentford Football Club | West Ham United Football Club | €23.1M | 29 January 2021 |
| 43 | Lucas Paquetá | Associazione Calcio Milan | Olympique Lyonnais | €23M | 30 September 2020 |
| 44 | Sébastien Haller | West Ham United Football Club | Ajax | €22.5M | 8 January 2021 |
| 45 | Thiago Alcántara | FC Bayern München | Liverpool Football Club | €22M | 18 September 2020 |
| 46 | Abdoulaye Doucouré | Watford FC | Everton Football Club | €22M | 8 September 2020 |
| 47 | Simone Verdi | Società Sportiva Calcio Napoli | Torino Calcio | €22M | 1 September 2020 |
| 48 | Suso | Associazione Calcio Milan | Sevilla Fútbol Club S.A.D. | €21.7M | 21 July 2020 |
| 49 | Sergiño Dest | Ajax | Futbol Club Barcelona | €21M | 1 October 2020 |
| 50 | Andrea Pinamonti | Genoa Cricket and Football Club | Inter | €21M | 18 September 2020 |